Asian Journal of Medical Principles and Clinical Practice

Effect of Morinda Lucida Leaf Extract on Ibuprofen Induced Nephrotoxicity Albino Rats

Nkiruka Millicent Amadi

Department of Medical Laboratory Science, Enugu State University of Science and Technology, Enugu State, Nigeria.

Peter Uwadiegwu Achukwu

Department of Medical Laboratory Science, University of Nigeria, Enugu Campus, Enugu State, Nigeria.

Emmanuel Ifeanyi Obeagu *

Department of Medical Laboratory Science, Imo State University, Owerri, Imo State, Nigeria.

Nonyelum V. Anoh

Department of Medical Laboratory Science, Enugu State University of Science and Technology, Enugu State, Nigeria.

*Author to whom correspondence should be addressed.

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Abstract

Morinda lucida ethanol stem bark extract dilution of ((500, 1000, 1500) mg /kg) body weight were administered to B_1, B_2, B₃ groups subjected to ibuprofen induced nephrotoxicity. Histomorphological studies on target organ; kidney were harvested, weighed and processed. Ibuprofen toxic activities of the extracts treated groups (serum biochemical markers) and the relative organ index (ρ<0.05) in treated groups respectively produce significant changes. Target organ extract examinations offered some protection on glomerular and tubular degenerative changes while there are deterioration changes in B groups.

Keywords: Toxicity, Ibuprofen, Kidney, nephrotoxicity, albino rats

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