Asian Journal of Medical Principles and Clinical Practice

Secondary Breast Angiosarcoma: A Case Report and Review of Literature

Woroud Raed Fauomi

Faculty of Medicine, Hashemite University, Zarqa, Jordan.

Bushra Hussain Abu Zaid

Faculty of Medicine, Hashemite University, Zarqa, Jordan.

Mohammad Saleh Alshare *

Breast Unit, General Surgery Department, Al-Bashir Hospital, Amman, Jordan.

Nizar Abu-oddos

Sahlgrenska University Hospital, Sweden.

Mohammad Abu-Jeyyab

School of Medicine, Mutah University, Al-Karak, Jordan.

*Author to whom correspondence should be addressed.

---

Abstract

Angiosarcoma a very aggressive tumor of the vascular endothelium with a different clinical presentation that have been shown between primary and secondary patterns, but both represented a diagnostics challenge because of the nonspecific imaging finding in disease.

Secondary angiosarcoma which is still a rare neoplasm presented in female patient as a palpable unilateral mass after long term exposure to radiation therapy for breast cancer, final diagnosis needs a pathological report which is obtained post-surgical that’s why preoperative diagnosis by using imaging modalities and biopsy is important to avoid misdiagnosis to this rare neoplasm.

We reported a special case of 61 female patient with secondary angiosarcoma arises near the scar of previous breast surgery due to invasive ductal carcinoma, patient was exposed to radiation therapy, chemotherapy and have positive family history.

Keywords: Angiosarcoma, breast cancer, secondary breast angiosarcoma, prognosis, case report, breast, angiosarcoma

---

---

---

References

Wyld L, Markopoulos C. Breast Cancer Management for Surgeons; 2018.

Doi: 10.1007/978-3-319-56673-3

Consult S, Edition T, Mcgill JB, et al. The Washington Manual TM.; 2013.

Varghese B, Deshpande P, Dixit S, Koppiker CB, Jalnapurkar N. Primary angiosarcoma of the breast: A case report. J Radiol Case Rep. 2019;13(2): 15-25. DOI:10.3941/jrcr.v13i2.3449

Corporation LS. Practice of. 1975;5.

Conti M, Morciano F, Rossati C, et al. Angiosarcoma of the Breast: Overview of current data and multimodal imaging findings. J Imaging. 2023;9(5). DOI: 10.3390/jimaging9050094

Shah S, Rosa M. Radiation-associated angiosarcoma of the breast: Clinical and pathologic features. Arch Pathol Lab Med. 2016;140(5):477-481. DOI: 10.5858/arpa.2014-0581-RS

Cozen W, Bernstein L, Wang F, Press MF, Mack TM. The risk of angiosarcoma following primary breast cancer. Br J Cancer. 1999;81(3):532-536. DOI: 10.1038/sj.bjc.6690726

Bentley H, Roberts J, Hayes M, et al. The role of imaging in the diagnosis of primary and secondary breast angiosarcoma: Twenty-five-year experience of a provincial cancer institution. Clin Breast Cancer. 2023;23(2):e45-e53. DOI: 10.1016/j.clbc.2022.11.003

Dashevsky BZ, Charnoff-Katz K, Shin SJ, Babagbemi K, Rosenblatt R. A case of primary breast angiosarcoma. Radiol Case Reports. 2013;8(3): 741. DOI: 10.2484/rcr.v8i3.741

Arora TK, Terracina KP, Soong J, Idowu MO, Takabe K. Primary and secondary angiosarcoma of the breast. Gland Surg. 2014;3(1):28-34. DOI: 10.3978/j.issn.2227-684X.2013.12.03

Salminen SH, Sampo MM, Böhling TO, et al. Radiation-associated angiosarcoma of the breast: analysis of diagnostic tools in a registry-based population. Acta Radiol. 2022;63(1):22-27. DOI: 10.1177/0284185120980142

Fodor J, Orosz Z, Szabó E, et al. Angiosarcoma after conservation treatment for breast carcinoma: our experience and a review of the literature. J Am Acad Dermatol. 2006;54(3):499-504. DOI: 10.1016/j.jaad.2005.10.017

Pervaiz N, Colterjohn N, Farrokhyar F, Tozer R, Figueredo A, Ghert M. A systematic meta-analysis of randomized controlled trials of adjuvant chemotherapy for localized resectable soft-tissue sarcoma. Cancer. 2008;113(3):573-581. Available:https://doi.org/10.1002/cncr.23592

Frustaci S, Gherlinzoni F, De Paoli A, et al. Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial. J Clin Oncol off J Am Soc Clin Oncol. 2001;19(5): 1238-1247. DOI: 10.1200/JCO.2001.19.5.1238

Rosen PP, Kimmel M, Ernsberger D. Mammary angiosarcoma. The prognostic significance of tumor differentiation. Cancer. 1988;62(10):2145-2151. DOI:10.1002/10970142(19881115)62:10<2145::aid-cncr2820621014>3.0.co;2-o

Sher T, Hennessy BT, Valero V, et al. Primary angiosarcomas of the breast. Cancer. 2007;110(1):173-178. DOI: 10.1002/cncr.22784

Seinen JM, Styring E, Verstappen V, et al. Radiation-associated angiosarcoma after breast cancer: High recurrence rate and poor survival despite surgical treatment with R0 resection. Ann Surg Oncol. 2012; 19(8): 2700-2706. DOI: 10.1245/s10434-012-2310-x