Asian Journal of Medical Principles and Clinical Practice

In-vivo Models as a System for the Investigation and Screening of Antidiabetic Efficacy of Certain Drugs and Substances: A Review

Surya Pratap Gond *

School of Pharmaceutical Sciences, CSJM University Kanpur, Uttar Pradesh-208024, India.

Prachi Pandey

School of Pharmaceutical Sciences, CSJM University Kanpur, Uttar Pradesh-208024, India.

Ajay Kumar Gupta

School of Pharmaceutical Sciences, CSJM University Kanpur, Uttar Pradesh-208024, India.

A. Rajendiran

Bhupal Nobles University, Udaipur, Rajasthan, India.

Anju Singh *

School of Pharmaceutical Sciences, CSJM University Kanpur, Uttar Pradesh-208024, India.

*Author to whom correspondence should be addressed.

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Abstract

Diabetes mellitus is a chronic condition that affects a large number of people. The fundamental cause of this condition is a lack of insulin synthesis or reduced insulin action. A large variety of in vivo and in vitro models have been developed to investigate the antidiabetic effect's fundamental mechanism. Several approaches for determining the anti-diabetic properties of plant extracts or isolated chemicals have been reported to be successful. This review covers major animal models used for the study of antidiabetic effect of a drug or substance, that could help in the development of new medicine to treat diabetes more effectively and with fewer or no adverse effects.

Keywords: Diabetes, medicinal herbs, flavonoids, animal models

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