Neutrophil to Lymphocyte Ratio and Some Cytokines in Pateints with Schizophrenia after Antipsychotic Therapy in Southeast, Nigeria
Published: 2022-05-30
Page: 176-181
Issue: 2022 - Volume 5 [Issue 2]
Emmanuel Ifeanyi Obeagu
*
Department of Medical Laboratory Science, Imo State University, Owerri, Nigeria.
Bessie Nonyelum Esimai
Department of Medical Laboratory Science, Evangel University, Akaeze, Ebonyi State, Nigeria.
Loveth Ngozika Ugwu
Department of Medical Laboratory Science, Madonna University Nigeria, Elele Campus, Rivers State, Nigeria.
Gina Flor Ramos
Department of Pharmacognosy, Madonna University Nigeria, Elele Campus, Elele, Rivers State, Nigeria.
Stephen Dotun Adetoye
Ivano Frankivsk National Medical University, Ukraine.
Emmanuel Chukwuma Edupute
Department of Medical Laboratory Science, Madonna University Nigeria, Elele Campus, Rivers State, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
The aim of the current study was to evaluate neutrophil to lymphocyte ratio and the levels of IL-6, TNF- \(\alpha\) in patients with schizophrenia after six weeks of antipsychotic treatment with Risperidone and Clozapine. Total study sample of 50 subjects of schizophrenia patients and 50 apparently healthy subjects aged 25-60 years were recruited in this study. The cytokines 6 were measured by Enzyme Linked Immunosorbent Assay. The results showed increase in WBC (P=0.001), absolute neutrophil (P=0.000), NLR (P=0.025), IL-6 (P=0.000) and no significant difference in TNF- \(\alpha\) (P=0.059) and no significant difference in absolute lymphocyte of schizophrenia patients before treatment compared to after treatment In conclusion, there were significantly higher values in IL-6, WBC and Neutrophil levels of schizophrenic drug naïve subjects when compared with schizophrenic treated subjects. Tumour Necrosis Factor - alpha serum levels among schizophrenic drug naïve subjects and schizophrenic drug treated subjects showed similar mean values.
Keywords: Neutrophil to lymphocyte ratio (NLR), schizophrenia, antipsychotic drugs, cytokine, interleukin 6 (IL-6), tumour necrosis factor alpha (TNF-\(\alpha\))